Sadly, one female resident, 83-year-old Nelly Walsh, died as a result of the blaze at the Old Rectory Residential Home for the Elderly, Gumfreston, and another five were taken to Withybush Hospital, Haverfordwest, suffering from smoke inhalation.
Yesterday lunchtime, they were described as 'comfortable' by a hospital spokesperson.
Meanwhile, a further 13 residents were relocated to nearby care facilities.
The emergency services were alerted at approximately 3.30 am and two fire crews from Tenby were on the scene within six minutes.
Upon arrival, the crews discovered and fought a fire on the first floor, while additional crews were called in to evacuate the home's 19 residents.
"A thorough search and rescue operation was undertaken by fire crews using breathing apparatus and the residents were rescued and conveyed to hospital and nearby care facilities," said senior divisional officer, Tudor Morgan, of Mid and West Wales Fire Brigade.
"At the height of the fire, five fire appliances and 30 firefighters were in attendance," he continued.
"Due praise must be given to the crews for their sterling efforts and their rapid evacuation of the residents."
The cause of the fire has yet to be determined and the necessary preliminary inquiries have begun in conjunction with the police and fire service.
The tragedy has shocked and stunned the local community and the emergency services, who attended the scene, including firefighters and emergency fire control operators who said they were deeply saddened at the loss of life.
Mike Smith, the Welsh executive council member of the Fire Brigades Union, said: "Our thoughts and sympathies are with the families and friends of the residents at the Old Rectory Residential Home. Every death in a fire is felt very deeply by those who work in the fire service.
"The tragedy could have been much worse if so many had not been assisted to safety by the emergency services.
"The Fire Brigades Union National Integrated Risk Management Planning Department is carrying out its own fact-finding inquiry into this incident. It is very important for the whole of Wales and the UK for lessons to be learned."
Following the tragedy, Welsh Assembly health and social services minister, Jane Hutt, said: "I was extremely concerned to hear of the tragic event. My thoughts go out to the family who have lost an elderly relative and those who have friends and relatives still in hospital.
"Inevitably a tragedy of this nature gives us cause for thought about what lessons need to be learnt. A full investigation is already underway by the relevant authorities."
Added Rob Pickford, chief executive of the care standards inspectorate for Wales: "I was deeply concerned to hear of the tragic events and want to express my sympathy to those who have lost their relative and to those who have been injured.
"I can confirm that the care standards inspectorate is working with the fire service and the police to understand how this has happened and what lessons could to be learnt from the tragedy. It would not be appropriate to make any further comment until the investigations have been completed."